Fibroblast co-conspirators

Mutant and wild-type Ras: co-conspirators in cancer.

Although the functional interplay between mutant and wild-type Ras in driving tumor initiation and growth has been described, a clear picture of the precise ramifications and mechanisms of this association remains elusive, sometimes with conflicting conclusions. A report in this issue of Cancer Discovery tackles this question, which may have important implications for therapeutic strategies to ...

Conspirators in a Capital Crime: Co-deletion of p18 and p16/p14/p15 in Glioblastoma Multiforme

Glioblastoma multiforme (GBM) is one of the most dreaded cancer diagnoses due to its poor prognosis and the limited treatment options. Homozygous deletion of the p16/ p14/p15 locus is among the most common genetic alterations in GBM. Two recent studies have shown that deletion and mutation of another INK4 family member, p18, also drives the pathogenesis of GBM. This minireview will discuss the ...

Criminal Minds: Cav3.2 Channels Are the Culprits, but NMDAR Are the Co-Conspirators.

IN THE SPOTLIGHT Mutant and Wild-type Ras: Co-conspirators in Cancer

Authors’ Affi liations: 1 Curriculum in Genetics and Molecular Biology; 2 Department of Pharmacology, 3 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Corresponding Author: Channing J. Der, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599. Phone: 919-966-5634; Fax: 919-966...

Effect of Fibroblast Co-culture on In Vitro Maturation and Fertilization of Mouse Preantral Follicles